Overview:For women who are not ovulating regularly, the goal of treatment is to mature and ovulate a single egg—this is known as ovulation induction. In some cases, where ovulation of multiple eggs is desirable this can also easily be achieved.
Why is it done?
This technique is most often used in women with (polycystic ovarian syndrome), but can be used for many others including male factor infertility, endometriosis, advanced maternal age.
OVULATION INDUCTION WITH CLOMIPHENE CITRATE
Clomiphene citrate (Clomid, Serophene) is a commonly used ovulation induction medication. It is used primarily to treat women who have ovulation disorders as reflected by infrequent or irregular menstrual cycles. Clomiphene citrate works at the level of the brain and pituitary gland and facilitates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH, in turn, stimulate the ovaries to produce eggs and the ovarian hormones estradiol (E2) and progesterone (P4).
What To Expect
HOW TO TAKE CLOMIPHENE CITRATE
Clomiphene citrate is a tablet that a woman takes by mouth for 5 days, typically beginning on day 3 of her menstrual cycle. Before you start taking Clomid, your physician must confirm that you are not pregnant by performing a baseline ultrasound, pregnancy test, and hormone tests. The initial prescribed dosage of clomiphene is 50 to 100 mg (one or two tablets) daily at bedtime, or as prescribed by your physician. Monitoring of egg development is usually done with E2 and LH blood hormone tests and ultrasound scans of the ovaries to determine when the egg is mature. An injection of Ovidrel is then typically recommended to trigger the release of your egg. One of the biggest benefits of a trigger shot is the increased ability to correctly time intercourse at home or insemination in the office. If you are having timed intercourse, your physician will instruct you to have intercourse on the day of the trigger shot and then again 2 days later to increase potential chances for conception